Abstract Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner have been well described in previous reports. Besides H3K4me3. H4K20me3 is another catalytic product of SMYD3. https://foldlyers.shop/product-category/vinyl-record-accessories/