The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex. Here. we describe a degradation-independent mechanism of Vif-mediated antag... https://www.roneverhart.com/Almanac-Sunshine-Opportunity-Barrel-Aged-Hibiscus-Sour-single/