The laboratory-scale (in-vitro) microbial fermentation based on screening of process parameters (factors) and statistical validation of parameters (responses) using regression analysis. The recent trends have shifted from full factorial design towards more complex response surface methodology designs such as Box-Behnken design. Central Composite design. Apart from the optimisation met... https://www.ngetikin.com/amazing-find-Bolia-Loop-Rug-limited-choice/