Lysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events. The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that are specific for K63-Ub hydrolysis. RAP80 targets the five-member nuclear BRCC36 complex to K63-Ub chains at DNA double-strand breaks. https://www.ivoryjinelle.com/limited-price-Florida-State-FSU-Seminoles-Maroon-iPhone-13-Pro-Max-Skin-p44288-hot-buy/